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For the purposes of ASM, we proposed at § 512.705 that “risk indicator” refers to Hierarchical Condition Category (HCC) risk scores under the HCC risk adjustment model established by CMS under section 1853(a)(1) of the Act or the proportion of beneficiaries with dual eligible status used in calculating the complex patient scoring adjustment as defined at § 512.745(a)(3)

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demonstrated that intentional weight loss significantly improved the response of obese PsO patients to low-dose cyclosporine (67) This finding underscores the broader concept that improving metabolic health can enhance responsiveness to immunosuppressive treatments and provides a rationale for combining metabolic interventions with systemic therapies, including GLP-1RAs

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