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Figure 1 Previous studies have established that patients affected by PCOS with BMI in the highest quartile (≥30 Kg/m 2 ) have a very high risk of developing MS ( PCOS is often accompanied with altered gonadotropin levels, decreased levels of IGF-BP1, increased ovarian 17-hydroxiprogesterone (17-OHP) and androgen response to Gonadotropin-Releasing-Hormone agonists (GnRH-agonists)

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