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doi: 10.1016/j.bbrc.2004.09.220

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During the lytic phase of HSV-1, either in neurons or epithelial cells the virus expresses its genes in a cascade-dependent manner, with three major waves of transcription: first, the expression of immediate early genes (IE or alpha genes), followed by the expression of early genes (E or beta genes) and lastly, late genes (L or gamma genes)